Abstract
Methylsulfonamide substituted 2,4-thiazolidinedione 22c is a potent (EC50=0.01 microM, IA=1.19) and selective (more than 110-fold over beta1 and beta2 agonist activity) beta3 agonist. This compound has also been proven to be active and selective in an in vivo mode.
MeSH terms
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Adrenergic beta-3 Receptor Agonists*
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Animals
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Diabetes Mellitus, Type 2 / drug therapy
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Disease Models, Animal
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Humans
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Mice
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Mice, Knockout
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Mice, Transgenic
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Obesity / drug therapy
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Structure-Activity Relationship
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Thiazoles / chemical synthesis
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Thiazoles / chemistry
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Thiazoles / pharmacology*
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Thiazoles / therapeutic use
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Thiazolidinediones*
Substances
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Adrenergic beta-3 Receptor Agonists
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Thiazoles
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Thiazolidinediones
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2,4-thiazolidinedione